Tumorigenicity and lysis by natural killers.

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Tumorigenicity and lysis by natural killers

Detailed analysis of the natural killer (NK) activity directed at nontumorigenic cell lines and their transformed tumorigenic derivatives has revealed a paradox. On the one hand, a correlation has been found between the tumorigenic potential of chemically transformed fibroblast cell lines and their sensitivity to NK cells in vitro. Nontransformed cells (N-type cell lines) and cells tumorigenic ...

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We have previously described (1) the in vitro isolation of chemically transformed cell lines resistant (C type) and sensitive (I type) to rejection mechanisms operative in normal mice. The experiments reported here utilize these two classes of transformed fibroblastic cell lines (I and C type) along with the parental nontransformed cell line (N type) to analyze the resistance or sensitivity of ...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1981

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.153.1.89